EDUCATION AND EMPLOYMENT

College of Chemistry and Molecular Sciences, Wuhan University, B.S., 2000-2004,

College of Chemistry and Molecular Sciences, Wuhan University, Ph.D., 2004-2010, Organic Chemistry, supervisor Dr. Xiang Zhou

Universite Joseph Fourier, 2008-2009, Chemistry, supervisor Jean F. Constant

University of Virginia, 2009-2010, Organic Chemistry, supervisor Dr. Lin Pu

Wake Forest University, 2010-2011, supervisor Lindsay R. Comstock

College of Chemistry and Molecular Sciences, Wuhan University, A.P., 2012-

TEACHING

1. Teaching Organic Chemistry to undergraduates

2. Teaching  Advanced Bioorganic Chemistry to graduate students

3. Adviser, First prize of National College students' Challenge Cup

PROJECTS

1. General Programs, the National Natural Science Foundation of China, 2016, Study on the method of detecting multiple sites of methyl, hydroxymethyl and aldehyde cytosine in DNA and modification of cytosine hydroxymethyl.

2. Youth Fund, the National Natural Science Foundation of China, 2014, Design, synthesis, structure-activity relationship and activity study of novel inducible DNA methyltransferase and histone methyltransferase inhibitors.

3. State Key Laboratory of Natural and Biomimetic Drugs, Peking University, 2014,  20013BLKF249

RESEARCH FIELD

1. Small molecule probes: Develop small molecular probes targeting irregular nucleic acids such as methylated nucleic acids, Z-type DNA, base mismatch, G quadruplex structure, and cross-linked nucleic acids, which can selectively act on these special nucleic acid structures and sites, and combine the probe molecules with photoresponsive small molecules, drug molecules, and nanomaterials to achieve the purpose of selective detection or treatment.

2. Epigenetics: Develop highly selective and sensitive detection methods for DNA methylation, microRNA and circular RNA  and apply in clinical tumor samples. our team has made some achievements in the detection and regulation of modified nucleic acids, including epigenetically and artificially modified nucleic acids. In the next step, we hope to make some breakthroughs in the study of related biological functions and mechanisms at the gene level by these means, and really apply the detection technology to the early detection and diagnosis of clinical diseases.

PUBLICATIONS

1. Zhang Y.; Yan S.; Chen Z.; Jiang X.; Rao S.; Jiang Z.; Qin S.; Zhou X.; Du Y. D ; Visually Intracellular Detection of Telomerase Activity Based on DNA Strand Displacement Reaction and Gold Nanoparticle Labeling, Chinese Journal of Chemistry, 2022, 40: 693-698

2. Yajun Zhang; Qiuyang Zhang; Xiaocheng Weng; Yuhao Du Y ; Xiang Zhou ; NEase-based amplificat ion for detection of miRNA, multiple miRNAs and circRNA, Analytica Chimica Acta, 2021, 1145: 52-5 8

3. Yaqian Liu, Xiong Zhang, Min Liu, Fa Xu, Qiuyang Zhang, Yajun Zhang, Xiaocheng Weng, Songmei Liu, Yuhao Du*, Xiang Zhou, Direct detection of circRNA in real samples using reverse transcription-rolling circle amplification, Anal. Chim. Acta., 2020, 1101: 169-175,

4. Min Liu, Wu Fan, Yuhao Du*, Xiang Zhou*, Specific stabilization of DNA G-quadruplex structures with a chemically modified complementary probe，Bioorg. Med. Chem. 2019, 27, 1962

5. Yinong Liu, Cheng Zhong, Zhiyong He, Shuang Rao, Haomiao Su, Fan Wu, Boshi Fu, Jinjun Wu, Yanyan Song, Yuhao Du*, and Xiang Zhou* . Sensors and Actuators B, 2018, 255, 2151

6. Zhiyong He, Chen, Yuqi Chen, Yafen Wang, Jiaqi Wang, Jing Mo, Boshi Fu, Zijing Wang, Xiang Zhou*, Yuhao Du*, A rapidly photo-activatable light-up fluorescent nucleoside and its application in DNA base variation sensing, Chem. Commun, 2016, 52, 8545.

7. Shuang Rao, Yuqi Chen, Tingting Hong, Zhiyong He, Shan Guo, Han Lai, Ge Guo, Yuhao Du*，Xiang Zhou*，Simultaneous and Sensitive Detection of Multisite 5-Methylcytosine Including Non-CpG Sites at Single-5mC-Resolution. Anal. Chem, 2016, 88, 10547.

8. Yuhao Du*, Xiang Zhou*, Targeting non-B-form DNA in living cells. Chem. Rec, 2013, 371.

9. Yuhao Du, Charles Hendrick, Krysta Frye, Lindsay Comstock*, Fluorescent DNA labeling by N-mustard analogues of S-adenosyl-L-methionine. ChemBioChem, 2012, 13, 2225.

10. Mark Turlington, Yuhao Du, Samuel G Ostrum, Wren Vishaka, Tony Lin, Michal Sabat，Lin Pu*, From highly enantioselective catalytic reaction of 1,3-diynes with aldehydes to facile asymmetric synthesis of polycyclic compounds. J. Am. Chem. Soc., 2011, 133, 11780。

11. Yuhao Du, , Xiaocheng Weng, Jing Huang, Dan Zhang, Heng Ma, Dong Chen, Xiang Zhou*, Constant, Jean-Francois, Oligonucleotide-selenide conjugate: synthesis and its inducible sequence-specific alkylation of DNA. Bioorg. Med. Chem. 2010, 18, 4149.

12. Yuhao Du, Mark Turlington, Xiang Zhou, Lin Pu*, Highly enantioselective addition of linear alkyl alkynes to linear aldehydes. Tetrahedron Lett., 2010, 51, 5024. (IF: 2.259, 三区)

13. Yuhao Du, Dan Zhang, Wei Chen, Ming Zhang, Yangyang Zhou, Xiang Zhou*, Cationic N-confused porphyrin derivative as a better molecule scaffold for G-quadruplex recognition. Bioorg. Med. Chem. 2010, 18, 1111.

14. Yuhao Du, Jing Huang, Xiaocheng Weng, Xiang Zhou*, Specific Recognition of DNA by Small Molecules. Curr. Med. Chem. 2010, 17, 173.