National Science Fund for Distinguished Young Scholars, 2004

Grand Prize of the tenth Natural Science Outstanding Academic Paper, Hubei Association for Science and Technology, 2004

Trans-Century Training Programme Foundation for the Talents, the State Education Commission, 2002

APPOINTMENTS, FELLOW/MEMBERSHIPS

1. Member, Chemistry Group of the Sixth and Seventh Discipline Review of the State Council Academic Degrees Committee

2. Member, the 7th Science and Technology Committee and the Department of Chemistry and Chemical Engineering, Ministry of Education

3. Member, The 11th, 12th and 15th Expert Review Group of the Department of Chemical Sciences, National Natural Science Foundation of China

4. Member of the Expert Guidance Group, Major Program of National Natural Science Foundation of China: Mechanisms of regulatory action of non-coding RNAs in the process of gene information transmission (2014- )

5. Member, The 28th and 29th Council of the Chinese Chemical Society

6. Director, Committee of Chemical Biology, Chinese Chemical Society (2016-2019)

7. Member, Academic Committee of Key Laboratory of Bioorganic and Molecular Engineering, Ministry of Education

8. Vice Chairman, Hubei Provincial Chemistry and Chemical Engineering Society

PUBLICATIONS

1. Su, H. M., Xu, J. L., Chen, Y. Q., Wang, Q., Lu, Z. A., Chen, Y. G., Chen, K., Han, S. Q., Fang, Z. T., Wang, P., Yuan, B. F., and Zhou, X.*, Photoactive G Quadruplex Ligand Identifies Multiple G Quadruplex Related Proteins with Extensive Sequence Tolerance in the Cellular Environment, J. Am. Chem. Soc., 2021, 10.1021/jacs.0c10792

2. Weng, X. C., Gong, J., Chen, Y., Wu, T., Wang, F., Yang, S. X., Yuan, Y. S., Luo, G. Z., Chen, K., Hu, L. L., Ma, H. H., Wang, P. L., Zhang, Q. F. C.*, Zhou, X.*, He, C.*, Keth-seq for transcriptome-wide RNA structure mapping. Nat. Chem Biol., 2020, 16, 489-492.

3. Peng, S., Bie, B. L., Jia, H. N., Tang, H., Zhang, X., Sun, Y. Q., Wei, Q., Wu, F., Yuan, Y. S., Deng, H. X.*, Zhou, X.*, Efficient Separation of Nucleic Acids with Different Secondary Structures by Metal–Organic Frameworks. J. Am. Chem. Soc., 2020, 142, 11, 5049-5059.

4. Wang, S. R., Wu, L. Y., Huang, H. Y., Xiong, W., Liu, J., Wei, L., Yin, P., Tian, T.*, Zhou, X.*, Conditional control of RNA-guided nucleic acid cleavage and gene editing. Nat Commun., 2020, 11:91.

5. Chen, Y. Q., Wu, F., Chen, Z. G., He, Z. Y., Wei, Q., Zeng, W. W., Chen, K., Xiao, F., Yuan, Y. S., Weng, X. C., Zhou, Y., Zhou, X.*, Acrylonitrile-Mediated Nascent RNA Sequencing for Transcriptome-Wide Profiling of Cellular RNA Dynamics. Adv. Sci., 2020, 7:1900997.

6. Su, H. M., Xu, J. L., Wang, Q., Wang, F. A., Zhou, X.*, High-efficiency and integrable DNA arithmetic and logic system based on strand displacement synthesis. Nat. Commun., 2019, 10, 5390.

7. Wang, Y. F., Zhang, X., Zou, G. R., Peng, S., Liu, C. X. and Zhou, X.*, Detection and application of 5-formylcytosine and 5-formyluracil in DNA, Acc. Chem. Res., 2019, 52,1016-1024. (Supplementary Cover)

8. Bian, W. X., Xie, Y., Wang, X. N., Xu, G. H., Fu, B. S., Li, S., Long, G., Zhou, X.* and Zhang, X. L.,* Binding of cellular nucleolin with the viral core RNA G-quadruplex structure suppresses HCV replication, Nucleic Acids Res., 2019, 47, 56-68.

9. Wang, S. R., Wang, J. Q., Fu, B. S.,Chen, K., Xiong, W., Wei, L., Qing, G. Y., Tian, T.*, and Zhou, X.*, Supramolecular Coordination-Directed Reversible Regulation of Protein Activities at Epigenetic DNA Marks, J. Am. Chem. Soc. 2018, 140, 15842−15849.

10.Peng, S., Bie, B. L., Sun, Y. Z., Liu, M., Cong, H. J., Zhou, W. T., Xia, Y. C., Tang, H., Deng, H. X.,* and Zhou, X.*, Metal-Organic Frameworks for Precise Inclusion of Single StrandedDNA and Transfection in Immune Cells, Nat. Commun., 2018, 9:1293.

11. Liu, C. X., Zou, G. R., Peng, S., Wang, Y. F., Yang, W., Wu, F., Jiang, Z. R., Zhang, X., and Zhou, X.*, 5-Formyluracil as a Multifunctional Building Block in Biosensor Designs, Angew. Chem. Int. Ed., 2018, 57, 9689-9693.

12. Hong, T. T., Yuan, Y. S., Chen, Z. C., Xi, K., Wang, T. L., Xie, Y. L., He, Z. Y., Su, H. M. , Zhou, Y., Tan, Z. J., Weng, X. C.*, and Zhou, X.*, Precise antibody-independent m6A identification via 4SedTTP-involved and FTO-assisted strategy at single-nucleotide resolution, J. Am. Chem. Soc., 2018, 140, 5886−5889. (Cover, Spotlights on Recent JACS Publications)

13. Tian, T., Chen, Y. Q., Wang, S. R.* and Zhou, X.*, G-Quadruplex: A Regulator of Gene Expression and Its Chemical Targeting, Chem, 2018, 4, 1314–1344.

14. Chen, Y. Q., Hong, T. T., Wang, S. R., Mo, J., Tian, T.*, Zhou, X.* Epigenetic modification of nucleic acids: from basic studies to medical applications. Chem. Soc. Rev., 2017, 46, 2844-2872.

15. Wang, S. R., Song, Y. Y., Wei L., Liu, C. X., Fu, B. S., Wang, J. Q., Yang X. R., Liu Y. N., Liu S. M., Tian, T.*, Zhou, X.* Cucurbit[7]uril-Driven Host−Guest Chemistry for Reversible Intervention of 5-Formylcytosine-Targeted Biochemical Reactions, J. Am. Chem. Soc.,2017, 139, 16903−16912. (Spotlights on Recent JACS Publications)

16. Tian, T., Song, Y. Y., Wei L., Wang, J. Q., Fu, B. S., He, Z. Y., Yang, X. R., Wu, F., Xu, G. H., Liu, M. S., Li, C. G., Wang, S. R.*, Zhou, X.*Reversible manipulation of the G-quadruplex structures and enzymatic reactions through supramolecular host–guest interactions, Nucleic Acids Res., 2017, 45, 2283–2293.

17. Wang, S. R., Min, Y. Q., Wang, J. Q., Liu, C. X., Fu, B. S., Wu, F., Wu, L. Y., Qiao, Z. X., Song, Y. Y., Xu, G. H., Wu, Z. G., Huang, G., Peng, N. F., Huang, R., Mao, W. X., Peng, S., Chen, Y. Q., Zhu, Y., Tian, T.*, Zhang, X. L.*, Zhou, X.*, A highly conserved G-rich consensus sequence in hepatitis C virus core gene represents a new anti–hepatitis C target, Sci. Adv., 2016, 2, e1501535.

18. Tian, T., Song, Y. Y., Wang, J. Q., Fu, B. S., He, Z. Y., Xu, X. Q.; Li, A. L., Zhou, X., Wang, S. R.*, Zhou, X.*, Small-Molecule- Triggered and Light-Controlled Reversible Regulation of Enzymatic Activity, J. Am. Chem. Soc., 2016, 138, 955-961.

19. Wang, T. L., Hong,T. T., Huang, Y., Su, H. M., Wu, F., Chen, Y., Wei, L., Huang, W., Hua, X. L., Xia, Y., Xu, J. L., Gan, J. H., Yuan, B. F., Feng, Y. Q., Zhang, X.L., Yang, C. G.*, Zhou, X.*, Fluorescein Derivatives as Bifunctional Molecules for the Simultaneous Inhibiting and Labeling of FTO Protein, J. Am. Chem. Soc., 2015, 137, 13736-13739.

20. Wang, S. R., Long, Y. L., Wang, J. Q., Ge, Y. S., Guo, P., Liu, Y., Tian, T.* Zhou, X.*, Systematic investigations of different cytosine modifications on CpG dinucleotide sequences: The effects on the B-Z transition. J. Am. Chem. Soc., 2014. 136, 56-59.

21. Wang, T. L., Hong, T. T., Tang, T., Zhai, Q. Q., Xing, X. W., Mao, W. X., Zheng, X. L., Xu, L., Wu, J. J., Weng, X. C.,Wang, S. R.,Tian, T.,Yuan,B. F., Huang, B., Zhuang, L. Zhou, X.*, Application of N-Halogeno-N- sodiobenzene sulfonamide Reagents to the Selective Detection of 5-Methylcytosine in DNA Sequences. J. Am. Chem. Soc., 2013, 135, 1240-1243.

22. Wu, Z. G., Tian, T., Yu, J. P., Weng, X. C., Liu, Y. Zhou, X.*, Formation of Sequence㊣ndependent Z〥NA Induced by a Ruthenium Complex at Low Salt Concentrations. Angew. Chem. Int. Ed., 2011, 50, 11962-11967.

23. Wang, X. L., Huang, J., Zhou, Y. Y., Yan, S. Y., Weng, X. C., Wu, X. J., Deng, M. G., Zhou, X.*, Conformational Switching of G㏎uadruplex DNA by Photoregulation. Angew. Chem. Int. Ed., 2010, 49, 5305-5309.

24. Bai, M. H., Huang, J., Zheng, X. L., Song, Z. B., Tang, M. R., Mao, W. X., Yuan, L. B., Wu, J., Weng, X. C., Zhou, X.*, Highly selective suppression of melanoma cells by inducible DNA cross-linking agents: bis (catechol) derivatives. J. Am. Chem. Soc., 2010, 132, 15321-15327.

25. Deng, M. G., Zhang, D., Zhou, Y. Y., Zhou, X.*, Highly effective colorimetric and visual detection of nucleic acids using an asymmetrically split peroxidase DNAzyme. J. Am. Chem. Soc., 2008, 130, 13095-13102.

26. Weng, X. C., Ren, L. G., Weng, L. W., Huang, J., Zhu, S. G., Zhou, X.*, Weng, L. H., Synthesis and Biological Studies of Inducible DNA Cross-Linking Agents. Angew. Chem. Int. Ed., 2007, 46, 8020-8023.

27. Wang, P., Liu, R. P., Wu, X. J., Ma, H. J, Cao, X. P., Zhou, P., Zhang, J. Y., Weng, X. C., Zhang, X. L. Qi, J., Zhou, X.*, Weng, L. H., A potent, water-soluble and photoinducible DNA cross-linking agent. J. Am. Chem. Soc., 2003, 125, 1116-1117.